Channels
Log in register
piqd uses cookies and other analytical tools to offer this service and to enhance your user experience.

Your podcast discovery platform

Curious minds select the most fascinating podcasts from around the world. Discover hand-piqd audio recommendations on your favorite topics.

You are currently in channel:

Health and Sanity

Rashmi Vasudeva
Features writer on health, lifestyle and the Arts, digital marketing blogger, mother
View piqer profile
piqer: Rashmi Vasudeva
Monday, 30 April 2018

Understanding Depression: Game-Changer Study Reveals New Clues About Genetic Risks

Last week, there was a major scientific breakthrough in our understanding of depression — one that can potentially revolutionize the treatment of this widespread condition.

Though it has long been suspected that depression (like many other mental ailments) runs in families, the hows and whys have been largely ambiguous. The age-old question of Nature versus Nurture has played a significant role in brewing up controversies about the disease. Is the offspring of a depressed mother at a higher risk because of his genes or because of her (assumed) inadequate parenting and a possibly cold growing-up environment? In other words, nature or nurture?

Much research has gone into finding a specific answer, but scientists have been bogged down by inconsistent findings. Which is why this particular study has caused such a flurry of excitement.

Scientists now know something concrete about the genetics of depression — the new study has identified 44 genes that contribute to the transmission of the risk of depression from one generation to the next. The multinational study is unprecedented in its scale and scope. Conducted by the Psychiatric Genomics Consortium consisting of more than 200 scientists, the analysis took into consideration 344,000 controls to test more than 135,000 people with depression.

As the lead authors explain, this study marks a major step in understanding the "biological underpinnings of depression", which can be used to improve therapies, especially with regard to targeted antidepressant medications.

Another discovery the study has made is how the genetic basis of depression overlaps greatly with that of schizophrenia and bipolar disorder.

What does this tell us?

Prof Edward Bullmore has the answer:

"This is telling us that we shouldn’t be thinking about a black-and-white distinction between us and them, between depressed patients and healthy people: it is much more likely that our complex genetic inheritance puts all of us on a continuous spectrum of risk."

Understanding Depression: Game-Changer Study Reveals New Clues About Genetic Risks
6.7
One vote
relevant?

Would you like to comment? Then register now for free!