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Health and Sanity

Rashmi Vasudeva
Features writer on health, lifestyle and the Arts, digital marketing blogger, mother
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piqer: Rashmi Vasudeva
Thursday, 09 November 2017

The Brain Is Not A Privileged Organ – Says The Immune System

This is big news for many reasons. Not only is this the most ambitious new trial in schizophrenia treatment in recent years but also further proof (if it was needed) that our immune system is at the heart of many of our illnesses.

Or as this article says, Descartes was wrong. The mind and the body are not separate entities – there exists no ‘blood-brain barrier’ that separates our brain from the immune system – a persistent belief that has led many a scientist into research dead-ends.

And it is not just about schizophrenia. A range of mental disorders from depression to dementia is increasingly being linked to our immune activity.

Evidence has been converging from several fields that immune cells in the brain play a significant role in causing schizophrenia by going into a sort of overdrive. The trial takes off from this point; the first patient was treated at King's Hospital, London last week. In the next two years, 30 patients will be injected with an antibody drug that is currently used to treat multiple sclerosis. The team of British researchers lead by Oliver Howes, a professor of molecular psychiatry, hopes this drug will be better able to target the root causes of schizophrenia as well as help them understand the biology of the illness in a more thorough manner. This is because the current drugs used to treat the illness only block dopamine to bring psychotic symptoms under control but do nothing to protect the brain from structural damage.

Why this particular trial assumes greater significance is because it hints at a massive change in the way scientists are looking at mental illnesses. As Howes says, “it's challenging the idea that the brain is this separate privileged organ.”

The Brain Is Not A Privileged Organ – Says The Immune System
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