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Health and Sanity

Rashmi Vasudeva
Features writer on health, lifestyle and the Arts, digital marketing blogger, mother
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piqer: Rashmi Vasudeva
Thursday, 14 December 2017

Landmark Trial Sparks Excitement: Light In The Neurodegenerative Tunnel At Last

There is unusual elation about this trial; even the media reports reflect it. A landmark trial it certainly is but some trials are more equal than others. This time around it all seems justified though. Experts are even saying that it is the biggest breakthrough in neurodegenerative diseases for 50 years. It is not often that neurodegenerative diseases see any light – researchers have been ploughing through dark tunnels for decades when it comes to diseases like Huntington’s, Parkinson’s and Alzheimer’s.

Researchers at the University College London have announced that there could be a drug soon that could significantly slow down the progress of Huntington’s disease, a genetic illness that the BBC says patients describe as “Parkinson’s, Alzheimer’s and motor neurone disease rolled into one.”

The unstoppable progress of Huntington’s disease leaves patients and their families completely devastated – the death of brain cells that occurs due to the disease affects everything from movement to behaviour to cognition. Caused by a gene defect that is inherited, most patients die within a decade of diagnosis. The experimental drug that is being hailed now was injected into the spinal fluid and it successfully lowered the quantity of toxic proteins in the brain.

The trial has caused ripples of excitement the world over because of the possibility of using the same approach in other neurodegenerative diseases such as Parkinson’s and dementia. They are also believed to be caused partly due to the build-up of toxic proteins in the brain.

Groundbreaking it certainly is, but as Prof Giovanna Mallucci cautions, it is not a cure and it will still be a "big leap" to make "gene silencing" work for all neurodegenerative diseases. Nevertheless, for scientists struggling for years, it is certainly a momentous first step. 

Landmark Trial Sparks Excitement: Light In The Neurodegenerative Tunnel At Last
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