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Health and Sanity

Rashmi Vasudeva
Features writer on health, lifestyle and the Arts, digital marketing blogger, mother
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piqer: Rashmi Vasudeva
Tuesday, 28 March 2017

Bad Luck Twice Over

Not exactly a cheery recommendation this – really, when has cancer been anything but bad news? But to know and not just suspect that it has always walked hand-in-hand with "bad luck" is depressing, to say the least. This new knowledge potentially transforms how scientists and doctors will look at cancer prevention in the future.

Last week, US researchers published a study in the journal Science that flatly attributes two-thirds of cancers to "random mistakes in DNA" that occur when normal cells make copies of themselves. This perhaps explains why some of the healthiest people in the world are stricken by cancer. The researchers likened this to typos that occur even when the best of typists are working on the best of keyboards. 

Curiously, this is the same group of researchers who in 2015 published a similar study in the same journal that asserted that such "DNA typos" cause more cancers than previously thought. This caused much brouhaha in the cancer community where traditionally it is believed that most cancers are caused by lifestyle and environmental factors, and thus more preventable. Fingers were pointed at the researchers for looking at cancers only in the US.

This new study though, is based on genetic sequencing and cancer studies from 69 countries. “Cancer might occur no matter how perfect the environment,” says the study author Dr Bert Vogelstein. With the help of a mathematical model, the researchers say 66% of cancers occur due to random mistakes, 29% due to lifestyle and environment factors and 5% due to heredity.

The researchers, this time around, have been careful enough to assert that though most cancers are due to bad luck, people should continue to maintain a healthy diet and lifestyle to avoid preventable cancers. The biggest takeaway from these findings though, is about how there ought to be more focus on early detection of cancers rather than other prevention strategies.

Bad Luck Twice Over
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